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1

Synthesis and evaluation of 2-pyrrolopyridinylquinoline derivatives as selective tau PET tracers for the diagnosis of Alzheimer's disease

Lerdsirisuk, Pradith, Harada, Ryuichi, Hayakawa, Yoshimi, Shimizu, Yuki, Ishikawa, Yoichi, Iwata, Ren, Kudo, Yukitsuka, Okamura, Nobuyuki, Furumoto, Shozo

Journal:

Nuclear Medicine and Biology

Year:

2021

File:

PDF, 1.33 MB

2021

2

The challenges of tau imaging

Villemagne, Victor L, Furumoto, Shozo, Fodero-Tavoletti, Michelle, Harada, Ryuichi, Mulligan, Rachel S, Kudo, Yukitsuka, Masters, Colin L, Yanai, Kazuhiko, Rowe, Chistopher C, Okamura, Nobuyuki

Journal:

Future Neurology

Year:

2012

Language:

english

File:

PDF, 1.98 MB

english, 2012

3

Tau PET Imaging in Alzheimer’s Disease

Okamura, Nobuyuki, Harada, Ryuichi, Furumoto, Shozo, Arai, Hiroyuki, Yanai, Kazuhiko, Kudo, Yukitsuka

Journal:

Current Neurology and Neuroscience Reports

Year:

2014

Language:

english

File:

PDF, 1.93 MB

english, 2014

4

Longitudinal Assessment of Tau Pathology in Patients with Alzheimer’s Disease Using [18F]THK-5117 Positron Emission Tomography

Ishiki, Aiko, Okamura, Nobuyuki, Furukawa, Katsutoshi, Furumoto, Shozo, Harada, Ryuichi, Tomita, Naoki, Hiraoka, Kotaro, Watanuki, Shoichi, Ishikawa, Yoichi, Tago, Tetsuro, Funaki, Yoshihito, Iwata, R

Journal:

Year:

2015

Language:

english

File:

PDF, 1.61 MB

english, 2015

5

A selective cyclooxygenase-2 inhibitor prevents inflammation-related squamous cell carcinogenesis of the forestomach via duodenogastric reflux in rats

Masaru Oba, Koichi Miwa, Takashi Fujimura, Shinichi Harada, Shozo Sasaki, Katsunobu Oyama, Tetsuo Ohta, Takanori Hattori

Journal:

Year:

2009

Language:

english

File:

PDF, 1.04 MB

english, 2009

6

Chemoprevention of glandular stomach carcinogenesis through duodenogastric reflux in rats by a COX-2 inhibitor

Masaru Oba, Koichi Miwa, Takashi Fujimura, Shinichi Harada, Shozo Sasaki, Takanori Hattori

Journal:

International Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 663 KB

english, 2008

7

A brassinolide biosynthetic pathway via 6-deoxocastasterone

Yong-Hwa Choi, Shozo Fujioka, Atsushi Harada, Takao Yokota, Suguru Takatsuto, Akira Sakurai

Journal:

Year:

1996

Language:

english

File:

PDF, 268 KB

english, 1996

8

An alternative brassinolide biosynthetic pathway via late C-6 oxidation

Choi Yong-Hwa, Shozo Fujioka, Takahito Nomura, Atsushi Harada, Takao Yokota, Suguru Takatsuto, Akira Sakurai

Journal:

Year:

1997

Language:

english

File:

PDF, 378 KB

english, 1997

9

Synthetic approach to identification of periplaneta sex pheromones

Takeo Harada, Takashi Takahashi, Shozo Takahashi

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 301 KB

english, 1992

10

Effects of strain and cultivation medium on the chemical composition of the taste components in fruit-body of Hypsizygus marmoreus

Akira Harada, Seiki Gisusi, Shozo Yoneyama, Masakazu Aoyama

Journal:

Year:

2004

Language:

english

File:

PDF, 398 KB

english, 2004

11

Thermal induced transition in the bonding nature of C60 molecules adsorbed on a Si(111)–(7×7) surface

Kazuyuki Sakamoto, Daiyu Kondo, Yoshimitsu Ushimi, Masashi Harada, Akio Kimura, Akito Kakizaki, Shozo Suto

Journal:

Journal of Electron Spectroscopy and Related Phenomena

Year:

1999

Language:

english

File:

PDF, 166 KB

english, 1999

12

MR imaging of the liver and complicating hepatic tumors in type Ia glycogen storage disease

Shozo Hirota, Koji Sugimoto, Shinichi Matsumoto, Michio Kono, Yasushi Harada

Journal:

International Journal of Clinical Oncology

Year:

1997

Language:

english

File:

PDF, 1.18 MB

english, 1997

13

Changes in contents of free amino acids and soluble carbohydrates during fruit-body development of Hypsizygus marmoreus

Akira Harada, Shozo Yoneyama, Shuichi Doi, Masakazu Aoyama

Journal:

Year:

2003

Language:

english

File:

PDF, 305 KB

english, 2003

14

Altered Glycosylation of Membrane Glycoproteins Associated with Human Mammary Carcinoma

Sen Hiraizumi, Seiichi Takasaki, Noriaki Ohuchi, Yuko Harada, Masato Nose, Shozo Mori, Akira Kobata

Journal:

Year:

1992

File:

PDF, 877 KB

1992

15

AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo

Mehmet Zeynel Cilek, Satoshi Hirohata, Omer Faruk Hatipoglu, Hiroko Ogawa, Toru Miyoshi, Junko Inagaki, Takashi Ohtsuki, Hiroshi Harada, Shigeshi Kamikawa, Shozo Kusachi, Yoshifumi Ninomiya

Journal:

Cell Biology International

Year:

2011

Language:

english

File:

PDF, 474 KB

english, 2011

16

Induction of extremely low protein expression level by fusion of C-terminal region of Nef

Nobutoki Takamune, Yukari Irisaka, Minami Yamamoto, Keisuke Harada, Shozo Shoji, Shogo Misumi

Journal:

Biotechnology and Applied Biochemistry

Year:

2012

Language:

english

File:

PDF, 1.57 MB

english, 2012

17

Optical time-division multiplexing scheme for fiber-optic millimeter-wave radio system

Hiroshi Harada, Shozo Komaka, Katsutoshi Tsukamoto, Norihiko Morinaga

Journal:

Electronics and Communications in Japan (Part II: Electronics))

Year:

1995

Language:

english

File:

PDF, 911 KB

english, 1995

18

Characterization of cell surface antigens expressed in the HMA-1 breast cancer cell line

Noriaki Ohuchi, Yuko Harada, Takashi Masuko, Shigeo Matano, Shozo Mori

Journal:

Year:

1995

Language:

english

File:

PDF, 1.16 MB

english, 1995

19

Omentum as gliding material after extensive forearm tenolysis

Koichi Ueda, Takao Harashina, Teruichi Harada, Shinichiro Oba, Shozo Nagasaka

Journal:

British Journal of Plastic Surgery

Year:

1993

Language:

english

File:

PDF, 538 KB

english, 1993

20

An experimental study of delay of flow-through venous flaps

Koichi Ueda, Teruichi Harada, Shozo Nagasaka, Sosuke Oba, Takeo Inoue, Takao Harashina

Journal:

British Journal of Plastic Surgery

Year:

1993

Language:

english

File:

PDF, 347 KB

english, 1993

21

Role of prostaglandin H synthase-2 in prostaglandin E2 formation in rat carrageenin-induced pleurisy

Yoshiteru Harada, Ko Hatanaka, Michiko Kawamura, Maki Saito, Michiko Ogino, Masataka Majima, Takashi Ohno, Keiko Ogino, Kei Yamamoto, Yutaka Taketani, Shozo Yamamoto, Makoto Katori

Journal:

Year:

1996

Language:

english

File:

PDF, 1.05 MB

english, 1996

22

In vitro comparative binding studies: Amyloid and tau imaging probes

Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Takeo Yoshikawa, Hiroyuki Arai, Yukitsuka Kudo, Kazuhiko Yanai

Journal:

Neuroscience Research

Year:

2011

Language:

english

File:

PDF, 70 KB

english, 2011

23

Synthesis of [11C]interleukin 8 using a cell-free translation system and l-[11C]methionine

Ryuichi Harada, Shozo Furumoto, Takeo Yoshikawa, Yoichi Ishikawa, Katsuhiko Shibuya, Nobuyuki Okamura, Ren Iwata, Kazuhiko Yanai

Journal:

Nuclear Medicine and Biology

Year:

2012

Language:

english

File:

PDF, 491 KB

english, 2012

24

Factor VIII contributes to platelet-fibrin thrombus formation via thrombin generation under low shear conditions

Chihiro Sugita, Atsushi Yamashita, Sayaka Moriguchi-Goto, Eiji Furukoji, Misaki Takahashi, Aya Harada, Tetsuhiro Soeda, Takehisa Kitazawa, Kunihiro Hattori, Shozo Tamura, Yujiro Asada

Journal:

Thrombosis Research

Year:

2009

Language:

english

File:

PDF, 547 KB

english, 2009

25

Near-infrared fluorescence probe X50 for in vivo detection of amyloid plaques in the brain

Nobuyuki Okamura, Shozo Furumoto, Ryuichi Harada, Hiroyuki Arai, Kazuhiko Yanai, Yukitsuka Kudo

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 54 KB

english, 2011

26

Novel 18F-labeled quinoline derivatives for in vivo detection of tau pathology in Alzheimer's disease

Nobuyuki Okamura, Shozo Furumoto, Ryuichi Harada, Michelle Fodero-Tavoletti, Victor Villemagne, Ren Iwata, Kazuhiko Yanai, Yukitsuka Kudo

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 356 KB

english, 2012

27

Bleomycin treatment for cancer of the thyroid

Tanekazu Harada, Yoshihiko Nishikawa, Takuya Suzuki, Kunihiko Ito, Shozo Baba

Journal:

The American Journal of Surgery

Year:

1971

Language:

english

File:

PDF, 2.33 MB

english, 1971

28

Use of a Benzimidazole Derivative BF-188 in Fluorescence Multispectral Imaging for Selective Visualization of Tau Protein Fibrils in the Alzheimer’s Disease Brain

Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto…

Journal:

Molecular Imaging and Biology

Year:

2014

Language:

english

File:

PDF, 1.04 MB

english, 2014

29

THK523 selectively binds to neurofibrillary tangles and neuropils in people with Alzheimer's disease

Fodero-Tavoletti, Michelle, Okamura, Nobuyuki, Taylor, Leanne, Furumoto, Shozo, McLean, Catriona, Mulligan, Rachel S., Birchall, Ian, Harada, Ryuichi, Masters, Colin, Yanai, Kazuhiko, Rowe, Christophe

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 519 KB

english, 2013

30

Wavelength-dependent selective detection of tau pathology in Alzheimer's disease using a novel fluorescent probe THK-1188

Harada, Ryuichi, Okamura, Nobuyuki, Furumoto, Shozo, Yoshikawa, Takeo, Arai, Hiroyuki, Kudo, Yukitsuka, Yanai, Kazuhiko

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 222 KB

english, 2012

31

Phenylquinoline derivatives for in vivo imaging of tau pathology in Alzheimer's disease

Okamura, Nobuyuki, Furumoto, Shozo, Harada, Ryuichi, Furukawa, Katsutoshi, Arai, Hiroyuki, Yanai, Kazuhiko, Kudo, Yukitsuka

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 52 KB

english, 2011

32

In vivo pattern of tau and beta-amyloid deposition in the brain might distinguish healthy controls from preclinical Alzheimer's disease

Villemagne, Victor, Furumoto, Shozo, Fodero-Tavoletti, Michelle, Mulligan, Rachel S., Harada, Ryuichi, Yates, Paul, Pejoska, Svetlana, Kudo, Yukitsuka, Masters, Colin, Yanai, Kazuhiko, Rowe, Christoph

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 154 KB

english, 2013

33

Binding characterization of novel PET tracer [18F]THK-5117 in the brains of people with Alzheimer's disease

Harada, Ryuichi, Okamura, Nobuyuki, Furumoto, Shozo, Tago, Tetsuro, Yoshikawa, Takeo, Arai, Hiroyuki, Iwata, Ren, Yanai, Kazuhiko, Kudo, Yukitsuka

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 330 KB

english, 2013

34

In vivo pattern of tau and beta-amyloid deposition in the brain might distinguish healthy individuals from those with preclinical Alzheimer's disease

Villemagne, Victor, Furumoto, Shozo, Fodero-Tavoletti, Michelle, Mulligan, Rachel S., Harada, Ryuichi, Yates, Paul, Pejoska, Svetlana, Yanai, Kazuhiko, Masters, Colin, Kudo, Yukitsuka, Rowe, Christoph

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 54 KB

english, 2013

35

In vivo detection of tau protein deposits in Alzheimer's disease using 18F-labeled 2-phenylquinoline derivatives

Okamura, Nobuyuki, Furumoto, Shozo, Harada, Ryuichi, Fodero-Tavoletti, Michelle, Mulligan, Rachel S., Masters, Colin, Yanai, Kazuhiko, Kudo, Yukitsuka, Rowe, Christopher, Villemagne, Victor

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 54 KB

english, 2013

36

In vivo evaluation of a novel tau imaging tracer for Alzheimer’s disease

Villemagne, Victor L., Furumoto, Shozo, Fodero-Tavoletti, Michelle T., Mulligan, Rachel S., Hodges, John, Harada, Ryuichi, Yates, Paul, Piguet, Olivier, Pejoska, Svetlana, Doré, Vincent, Yanai, Kazuhi

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2014

Language:

english

File:

PDF, 4.15 MB

english, 2014

37

Assessing THK523 selectivity for tau deposits in Alzheimer’s disease and non–Alzheimer’s disease tauopathies

Fodero-Tavoletti, Michelle T, Furumoto, Shozo, Taylor, Leanne, McLean, Catriona A, Mulligan, Rachel S, Birchall, Ian, Harada, Ryuichi, Masters, Colin L, Yanai, Kazuhiko, Kudo, Yukitsuka, Rowe, Christo

Journal:

Alzheimer's Research & Therapy

Year:

2014

Language:

english

File:

PDF, 967 KB

english, 2014

38

molecules and SiC-film surface phonons

Sakamoto, Kazuyuki, Suzuki, Toshinao, Harada, Masashi, Wakita, Takanori, Suto, Shozo, Kasuya, Atsuo

Journal:

Physical Review B

Year:

1998

Language:

english

File:

PDF, 213 KB

english, 1998

39

surface

Sakamoto, Kazuyuki, Harada, Masashi, Kondo, Daiyu, Kimura, Akio, Kakizaki, Akito, Suto, Shozo

Journal:

Physical Review B

Year:

1998

Language:

english

File:

PDF, 127 KB

english, 1998

40

Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging

Tago, Tetsuro, Furumoto, Shozo, Okamura, Nobuyuki, Harada, Ryuichi, Ishikawa, Yoichi, Arai, Hiroyuki, Yanai, Kazuhiko, Iwata, Ren, Kudo, Yukitsuka

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2014

Language:

english

File:

PDF, 997 KB

english, 2014

41

surfaces

Sakamoto, Kazuyuki, Kondo, Daiyu, Ushimi, Yoshimitsu, Harada, Masashi, Kimura, Akio, Kakizaki, Akito, Suto, Shozo

Journal:

Physical Review B

Year:

1999

Language:

english

File:

PDF, 398 KB

english, 1999

42

Prevalence of metabolic syndrome in stroke patients: a prospective multicenter study in Japan

Takahashi, Takeshi, Harada, Masahiro, Kikuno, Takaaki, Ujihara, Makoto, Sadamitsu, Daikai, Manabe, Yasuhiro, Yasaka, Masahiro, Takayama, Hayato, Kobori, Shozo, Araki, Eiichi

Journal:

Acute Medicine & Surgery

Year:

2014

Language:

english

File:

PDF, 80 KB

english, 2014

43

[18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer’s disease

Harada, Ryuichi, Okamura, Nobuyuki, Furumoto, Shozo, Furukawa, Katsutoshi, Ishiki, Aiko, Tomita, Naoki, Hiraoka, Kotaro, Watanuki, Shoichi, Shidahara, Miho, Miyake, Masayasu, Ishikawa, Yoichi, Matsuda

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2015

Language:

english

File:

PDF, 1.60 MB

english, 2015

44

Clearly different mechanisms of enhancement of short-lived Nef-mediated viral infectivity between SIV and HIV-1

Harada, Keisuke, Takamune, Nobutoki, Shoji, Shozo, Misumi, Shogo

Journal:

Virology Journal

Year:

2014

Language:

english

File:

PDF, 1.18 MB

english, 2014

45

Preclinical Evaluation of [18F]THK-5105 Enantiomers: Effects of Chirality on Its Effectiveness as a Tau Imaging Radiotracer

Tago, Tetsuro, Furumoto, Shozo, Okamura, Nobuyuki, Harada, Ryuichi, Adachi, Hajime, Ishikawa, Yoichi, Yanai, Kazuhiko, Iwata, Ren, Kudo, Yukitsuka

Journal:

Molecular Imaging and Biology

Year:

2016

Language:

english

File:

PDF, 1.01 MB

english, 2016

46

Advances in the development of tau PET radiotracers and their clinical applications

Okamura, Nobuyuki, Harada, Ryuichi, Furukawa, Katsutoshi, Furumoto, Shozo, Tago, Tetsuro, Yanai, Kazuhiko, Arai, Hiroyuki, Kudo, Yukitsuka

Journal:

Ageing Research Reviews

Year:

2016

Language:

english

File:

PDF, 770 KB

english, 2016

47

Validation of the binding specificity of Tau PET tracer [18F]THK-5351 on postmortem human brain samples

Harada, Ryuichi, Okamura, Nobuyuki, Furumoto, Shozo, Furukawa, Katsutoshi, Ishiki, Aiko, Tomita, Naoki, Tago, Tetsuro, Iwata, Ren, Yanai, Kazuhiko, Arai, Hiroyuki, Kudo, Yukitsuka

Journal:

Alzheimer's & Dementia

Year:

2015

Language:

english

File:

PDF, 48 KB

english, 2015

48

ACCUMULATION OF THE NOVEL TAU IMAGING TRACER 18F-THK-5117 IS ASSOCIATED WITH BRAIN ATROPHY IN ALZHEIMER'S DISEASE

Ishiki, Aiko, Furumoto, Shozo, Harada, Ryuichi, Furukawa, Katsutoshi, Okamura, Nobuyuki, Tashiro, Manabu, Yanai, Kazuhiko, Kudo, Yukitsuka, Arai, Hiroyuki

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 179 KB

english, 2014

49

Validation of the binding specificity of Tau PET tracer [18F]THK-5351 on postmortem human brain samples

Harada, Ryuichi, Okamura, Nobuyuki, Furumoto, Shozo, Ishiki, Aiko, Furukawa, Katsutoshi, Tomita, Naoki, Tago, Tetsuro, Iwata, Ren, Yanai, Kazuhiko, Arai, Hiroyuki, Kudo, Yukitsuka

Journal:

Alzheimer's & Dementia

Year:

2015

Language:

english

File:

PDF, 57 KB

english, 2015

50

BINDING CHARACTERIZATION OF TAU PET TRACER 18F-THK5117 IN NON-ALZHEIMER'S NEURODEGENERATIVE DISEASES

Harada, Ryuichi, Okamura, Nobuyuki, Furumoto, Shozo, Tago, Tetsuro, Yoshikawa, Takeo, Akatsu, Hiroyasu, Iwata, Ren, Arai, Hiroyuki, Yanai, Kazuhiko, Kudo, Yukitsuka

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 82 KB

english, 2014